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Downstream Processing Publications

Journal Articles:

  • Balasundaram B. and Harrison S.T.L. (2011). Optimising orifice geometry for selective release of periplasmic products using cell disruption by hydrodynamic cavitation. Biochemical Engineering Journal 54, 207-209.
  • Harrison S.T.L. (2011). Cell disruption. In Comprehensive Biotechnology 2nd Edition (Eds. M Moo-Young and C Webb), Vol 3, Chapter 127, in press
  • Balasundaram B, Harrison S T L and Bracewell D G. (2009). Developments in intracellular product release for whole bioprocess design strategies. Trends in Biotechnology 27 (8), 477-485.
  • Fan J and Harrison S.T.L. (2009). Effect of heat pretreatment on efficiency of microbial cell disruption. J. Tianjin Normal University (Natural Science Edition), 29(2), 69-72.
  • Balasundaram, B. and Harrison, S. T. L. (2008). Influence of method and extent of disruption of Bakers’ yeast on protein adsorption in expanded beds. Journal of Biotechnology 133, 360-369 [Impact factor 2.6].
  • Balasunsdaram, B., Harrison, S.T.L., Li, J. and Chase, H.A. (2008) A study of the influence of yeast cell debris on protein and -glucosidase adsorption at various zones within the expanded bed using in-bed sampling. Biotechnology and Bioengineering 99 (3), 614-624. [Impact factor 2.999].
  • Johnstone-Robertson, M, Clarke, K.G. and Harrison S.T.L. (2008) Comparison of the distribution of glucose oxidase in Penicillium sp. CBS 120262 and Aspergillus niger NRRL-3 cultures. Biotechnology and Bioengineering 99 (4) 910 - 918.
  • Anand H, Pandit A B, Balasundaram B and Harrison STL (2007). The effect of pre-treatment combined with mechanical disruption on the extent of disruption and subsequent release of intracellular protein from E.coli. Biochemical Engineering Journal, 35 (2), 166-173.
  • Balasundaram B and Harrison STL (2006). Study of physical and biological factors involved in the disruption of E.coli by hydrodynamic cavitation. Biotechnology Progress 22, 907-913.
  • Clarke K G, Johnstone-Robertson M and Harrison STL. (2006). Location of glucose oxidase during production by Aspergillus niger. Appl. Microbiol. Biotechnol. 70, 72-77
  • Balasundaram B and Harrison STL (2006). Disruption of Baker’s yeast by hydrodynamic cavitation: process variables and their influence on selective release. Biotechnology and Bioengineering 94 (2), 303 - 311. [Impact factor 2.999].
  • Farkade V.D., Harrison S T L and Pandit A B (2006). Improved cavitational cell disruption following pH pre-treatment for the extraction of -galactosidase from Kluveromyces lactis. Biochemical Engineering Journal 31, 25-30. [Impact factor 1.608].
  • Farkade V D, Harrison S T L and Pandit A B (2005). Heat induced translocation of proteins and enzymes within the cell: an effective way to optimise the microbial cell disruption process. Biochemical Engineering Journal, 23, 247-257.
  • Cilliers J.J. and Harrison S.T.L. (1998). Yeast separation using small diameter hydrocyclones. In Innovation in physical separation technologies (ed RA Williams), pp 121-129.
  • Cilliers J J and Harrison S T L (1996). The effect of viscosity on the recovery and concentration of micro-organisms using hydrocyclones. In Hydrocyclones ‘96 (eds Claxton D, Svarovsky L & Thew M), MEP, U.K., pp123-133.
  • Harrison S T L, Davies G M, Scholtz N J and Cilliers J J (1994). The recovery and dewatering of microbial suspensions using hydrocyclones. In Separation in Biotechnology 3 (ed D L Pyle), RSC, pp214-220.
  • Cilliers J J, Johnson L S and Harrison S T L (1994). Solid-liquid separation of poly-ß-hydroxybutyrate by froth flotation. In Separation in Biotechnology 3 (ed D L Pyle), RSC, pp113-119.
  • Harrison S.T., Dennis J.S. and Chase H.A. (1990). The effect of culture history on the disruption of Alcaligenes eutrophus by high pressure homogenisation. In Separations in Biotechnology Vol 2, pp38-47 (ed. D.L. Pyle). Elsevier Applied Science, London and New York.
  • Harrison S.T.L, Chase H.A. and Dennis J.S. (1991). The lysis of Gram-negative Alcaligenes eutrophus by enzymes from Cytophaga. Biotechnology Techniques, 5(2), 115-120.
  • Harrison S.T.L. (1991). Bacterial cell disruption: a key unit operation in the recovery of intracellular products. Biotechnology Advances, 9(2), 217-240.
  • Harrison S.T.L, Dennis J.S. and Chase H.A. (1991). Combined chemical and mechanical processes for the disruption of bacteria. Bioseparation, 2, 95-105.
  • Harrison S.T.L., Chase H.A. and Dennis J.S. (1991). The disruption of Alcaligenes eutrophus by high pressure homogenisation: Key factors involved in the process. Bioseparation, 2, 155-166.